Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation

BACKGROUND: BRCA1 gene inactivation causes chromosomal instability, leading to rapid accumulation of chromosomal rearrangements and mutations. The loss of BRCA1 function due to either germline/somatic mutation or epigenetic silencing is observed in most high-grade serous carcinomas of the ovary. MET...

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Autores principales: Pradhan, Manohar, Risberg, Björn Å, Tropé, Claes G, van de Rijn, Matt, Gilks, C Blake, Lee, Cheng-Han
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946313/
https://ncbi.nlm.nih.gov/pubmed/20843305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-493
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