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Tpl2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1β production
Tumor progression locus 2 (Tpl2, also known as Map3k8 and Cot) is a serine-threonine kinase critical in innate immunity, linking toll-like receptors (TLRs) to tumor necrosis factor (TNF) production through its activation of extracellular signal-regulated kinase (ERK). Tpl2(−/−) macrophages have abro...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2946069/ https://ncbi.nlm.nih.gov/pubmed/19933865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901336 |
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