Associations between HLA, PTPN22, CTLA4 genotypes and RA phenotypes of autoantibody status, age at diagnosis, and erosions in a large cohort study

BACKGROUND: HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with CCP+ RA. OBJECTIVE: We examined associations between HLA-SE, PTPN22, CTLA4 genotypes and RA phenotypes in a large cohort to (a) replicate prior associations with CCP status, and (b) determine associations with...

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Bibliografiske detaljer
Main Authors: Karlson, Elizabeth W., Chibnik, Lori B., Cui, Jing, Plenge, Robert M., Glass, Roberta J., Maher, Nancy E., Parker, Alex, Roubenoff, Ronenn, Izmailova, Elena, Coblyn, Jonathan S., Weinblatt, Michael E., Shadick, Nancy A.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945890/
https://ncbi.nlm.nih.gov/pubmed/17666451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2007.071662
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