p85β phosphoinositide 3-kinase regulates CD28 coreceptor function

CD28 is a receptor expressed on T cells that regulates their differentiation after antigen stimulation to long-term-survival memory T cells. CD28 enhances T-cell receptor signals and reduces expression of CBL ubiquitin ligases, which negatively control T-cell activation. In the absence of CD28 ligat...

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Main Authors: Alcázar, Isabela, Cortés, Isabel, Zaballos, Angel, Hernandez, Carmen, Fruman, David A., Barber, Domingo F., Carrera, Ana C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2009
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945823/
https://ncbi.nlm.nih.gov/pubmed/19190244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-04-152942
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