Characterization of the Time Course of Carbamazepine Deinduction by an Enzyme Turnover Model

BACKGROUND AND OBJECTIVE: Carbamazepine is a potent inducer of drug metabolizing enzymes, which results in a number of clinically significant drug-drug interactions. Deinduction occurs when chronic carbamazepine therapy is discontinued. The goal of this study was to develop a population pharmacokine...

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Main Authors:	Punyawudho, B., Cloyd, J.C., Leppik, I.E., Ramsay, R.E., Marino, S.E., Pennell, P.B., White, J.R., Birnbaum, A.K.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2009
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2945813/ https://ncbi.nlm.nih.gov/pubmed/19566114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2165/00003088-200948050-00003
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Characterization of the Time Course of Carbamazepine Deinduction by an Enzyme Turnover Model

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