Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. A novel strategy for the therapy of KS.

Kaposi's sarcoma (KS) is the most frequent tumor of HIV-1-infected individuals (AIDS-KS). Typical features of KS are proliferating spindle-shaped cells, considered to be the tumor cells of KS, and endothelial cells forming blood vessels. Basic fibroblast growth factor (bFGF), a potent angiogenic fac...

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Pubblicato in:	J Clin Invest
Autori principali:	Ensoli, B, Markham, P, Kao, V, Barillari, G, Fiorelli, V, Gendelman, R, Raffeld, M, Zon, G, Gallo, R C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294564/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7525646/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117521
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