Chemoenzymatic synthesis of the sialyl Lewis X glycan and its derivatives

A combination of recombinant FKP and α-(1→3)-fucosyltransferase allows the facile synthesis of the sialyl Lewis X tetrasaccharide glycan and its derivatives in excellent yield. In this system, the universal fucosyl donor, guanidine 5′-diphosphate-β-L-fucose (GDP-fucose), or its analogues can be gene...

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Main Authors: del Amo, David Soriano, Wang, Wei, Besanceney, Christen, Zheng, Tianqing, He, Yizheng, Gerwe, Brian, Seidel, Ronald D., Wu, Peng
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945603/
https://ncbi.nlm.nih.gov/pubmed/20435300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2010.03.032
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