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Loss of β1-Integrin Enhances TGF-β1-induced Collagen Expression in Epithelial Cells via Increased αvβ3-Integrin and Rac1 Activity
Transforming growth factor β (TGF-β) promotes tissue fibrosis via the receptor-specific Smad pathway and non-canonical pathways. We recently reported that TGF-β1-stimulated collagen expression by cultured kidney cells requires integrin-dependent activation of focal adhesion kinase (FAK) and conseque...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945568/ https://ncbi.nlm.nih.gov/pubmed/20650890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105700 |
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