Loss of β1-Integrin Enhances TGF-β1-induced Collagen Expression in Epithelial Cells via Increased αvβ3-Integrin and Rac1 Activity

Transforming growth factor β (TGF-β) promotes tissue fibrosis via the receptor-specific Smad pathway and non-canonical pathways. We recently reported that TGF-β1-stimulated collagen expression by cultured kidney cells requires integrin-dependent activation of focal adhesion kinase (FAK) and conseque...

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Hauptverfasser: Hayashida, Tomoko, Jones, Jonathan C. R., Lee, Carrie K., Schnaper, H. William
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945568/
https://ncbi.nlm.nih.gov/pubmed/20650890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105700
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