Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis

Proteolytic processing of the amyloid precursor protein (APP) generates large soluble APP derivatives, β-amyloid (Aβ) peptides, and APP intracellular domain. Expression of the extracellular sequences of APP or its Caenorhabditis elegans counterpart has been shown to be sufficient in partially rescui...

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Detalhes bibliográficos
Main Authors: Li, Hongmei, Wang, Zilai, Wang, Baiping, Guo, Qinxi, Dolios, Georgia, Tabuchi, Katsuhiko, Hammer, Robert E., Südhof, Thomas C., Wang, Rong, Zheng, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945554/
https://ncbi.nlm.nih.gov/pubmed/20693289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.137729
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