HMGB1 Release and Redox Regulates Autophagy and Apoptosis in Cancer Cells

The functional relationship and cross-regulation between autophagy and apoptosis is complex. Here we show that high-mobility group box 1 protein (HMGB1) is a redox-sensitive regulator of the balance between autophagy and apoptosis. In cancer cells, anti-cancer agents enhanced autophagy and apoptosis...

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Bibliographische Detailangaben
Hauptverfasser: Tang, Daolin, Kang, Rui, Cheh, Chun-Wei, Livesey, Kristen M., Liang, Xiaoyan, Schapiro, Nicole E., Benschop, Robert, Sparvero, Louis J., Amoscato, Andrew A., Tracey, Kevin J., Zeh, Herbert J., Lotze, Michael T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945431/
https://ncbi.nlm.nih.gov/pubmed/20622903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.261
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