High Fat Diet Increases Hippocampal Oxidative Stress and Cognitive Impairment in Aged Mice: Implications for decreased Nrf2 signaling

Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD consumption on brain aging are poorly understood. In the present study 20-month old male C57Bl/6 mice were fed either “Western Diet” (WD, 41% fat), very high fat lard diet...

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Autores principales: Morrison, Christopher D., Pistell, Paul J., Ingram, Donald K., Johnson, William D., Liu, Ying, Fernandez-Kim, Sun Ok, White, Christy L., Purpera, Megan N., Uranga, Romina M., Bruce-Keller, Annadora J., Keller, Jeffrey N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945419/
https://ncbi.nlm.nih.gov/pubmed/20557430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06865.x
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