H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation via heregulin production and activation of HER3

Hyperactivation of phosphatidylinositol-3 kinase (PI3K) can occur as a result of somatic mutations in PIK3CA, the gene encoding the p110α subunit of PI3K. The HER2 oncogene is amplified in 25% of all breast cancers and some of these tumors also harbor PIK3CA mutations. We examined mechanisms by whic...

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Detalhes bibliográficos
Main Authors: Chakrabarty, Anindita, Rexer, Brent N., Wang, Shizhen Emily, Cook, Rebecca S., Engelman, Jeffrey A., Arteaga, Carlos, L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945381/
https://ncbi.nlm.nih.gov/pubmed/20581867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.257
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