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Experimental Generation of SNP Haplotype Signatures in Patients with Sickle Cell Anaemia
BACKGROUND: Sickle cell anemia is caused by a single type of mutation, a homozygous A→T substitution in the ß globin gene. Clinical severity is diverse, partially due to additional, disease-modifying genetic factors. We are studying one such modifier locus, HMIP (HBS1L-MYB intergenic polymorphism, c...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945316/ https://ncbi.nlm.nih.gov/pubmed/20886046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013004 |
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