Mitochondrial DAMPs from femoral reamings activate neutrophils via formyl peptide receptors and P44/42 MAP Kinase

HYPOTHESIS: Fractures and femoral reaming are associated with lung injury. The mechanisms linking fractures and inflammation are unclear; but tissue disruption might release mitochondria. Mitochondria are evolutionarily derived from bacteria and contain “Damage Associated Molecular Patterns” (DAMPs)...

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Autores principales: Hauser, Carl J., Sursal, Tolga, Rodriguez, Edward K., Appleton, Paul T., Zhang, Qin, Itagaki, Kiyoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945259/
https://ncbi.nlm.nih.gov/pubmed/20736789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/BOT.0b013e3181ec4991
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