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p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy
The human transcription factor TP53 is a pivotal roadblock against cancer. A key unresolved question is how the p53 protein selects its genomic binding sites in vivo out of a large pool of potential consensus sites. We hypothesized that chromatin may play a significant role in this site-selection pr...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945185/ https://ncbi.nlm.nih.gov/pubmed/20716666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.103945.109 |
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