High Nucleosome Occupancy Is Encoded at Human Regulatory Sequences

Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters, enhancers, and TFBSs generally encodes high i...

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Bibliografiske detaljer
Main Authors: Tillo, Desiree, Kaplan, Noam, Moore, Irene K., Fondufe-Mittendorf, Yvonne, Gossett, Andrea J., Field, Yair, Lieb, Jason D., Widom, Jonathan, Segal, Eran, Hughes, Timothy R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817738/
https://ncbi.nlm.nih.gov/pubmed/20161746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009129
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