Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice

INTRODUCTION: Systemic inflammation in sepsis is initiated by interactions between pathogen molecular motifs and specific host receptors, especially toll-like receptors (TLRs). Flagellin is the main flagellar protein of motile microorganisms and is the ligand of TLR5. The distribution of TLR5 and th...

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Bibliografske podrobnosti
Main Authors: Rolli, Joëlle, Loukili, Noureddine, Levrand, Sandra, Rosenblatt-Velin, Nathalie, Rignault-Clerc, Stéphanie, Waeber, Bernard, Feihl, François, Pacher, Pal, Liaudet, Lucas
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945144/
https://ncbi.nlm.nih.gov/pubmed/20731882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc9235
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