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Asymmetric Total Synthesis of Vindorosine, Vindoline and Key Vinblastine Analogues
Concise asymmetric total syntheses of vindoline (1) and vindorosine (2) are detailed based on a unique intramolecular [4+2]/[3+2] cycloaddition cascade of 1,3,4-oxadiazoles inspired by the natural product structures. A chiral substituent on the tether linking the dienophile and oxadiazole was used t...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944909/ https://ncbi.nlm.nih.gov/pubmed/20809620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja106284s |
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