Germline Variation Controls the Architecture of Somatic Alterations in Tumors

Studies have suggested that somatic events in tumors can depend on an individual's constitutional genotype. We used squamous cell carcinomas (SCC) of the skin, which arise in high multiplicity in organ transplant recipients, as a model to compare the pattern of somatic alterations within and ac...

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Detalhes bibliográficos
Main Authors: Dworkin, Amy M., Ridd, Katie, Bautista, Dianne, Allain, Dawn C., Iwenofu, O. Hans, Roy, Ritu, Bastian, Boris C., Toland, Amanda Ewart
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944791/
https://ncbi.nlm.nih.gov/pubmed/20885788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001136
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