Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments

A computational methodology based on Metropolis Monte Carlo (MC) and the weighted histogram analysis method (WHAM) has been developed to calculate the absolute binding free energy between functionalized nanocarriers (NC) and endothelial cell (EC) surfaces. The calculated NC binding free energy lands...

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Bibliographic Details
Main Authors:	Liu, Jin, Weller, Gregory E. R., Zern, Blaine, Ayyaswamy, Portonovo S., Eckmann, David M., Muzykantov, Vladimir R., Radhakrishnan, Ravi
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2010
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2944711/ https://ncbi.nlm.nih.gov/pubmed/20823256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006611107
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Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments

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