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Inhibition of human factor VIIIa by anti-A2 subunit antibodies.

Human inhibitory alloantibodies and autoantibodies to Factor VIII (FVIII) are usually directed toward the A2 and/or C2 domains of the FVIII molecule. Anti-C2 antibodies block the binding of FVIII to phospholipid, but the mechanism of action of anti-A2 antibodies is not known. We investigated the pro...

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Detalhes bibliográficos
Main Authors: Lollar, P, Parker, E T, Curtis, J E, Helgerson, S L, Hoyer, L W, Scott, M E, Scandella, D
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC294465/
https://ncbi.nlm.nih.gov/pubmed/8200986
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