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Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.

Angiotensin II (Ang II) has been implicated in the development of progressive glomerulosclerosis, but the precise mechanism of this effect remains unclear. In an experimental model, we have shown previously that TGF-beta plays a key role in glomerulosclerosis by stimulating extracellular matrix prot...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Principais autores: Kagami, S, Border, W A, Miller, D E, Noble, N A
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1994
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294451/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8200978/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117251
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