Lipopolysaccharides directly decrease Ca(2+) oscillations and the hyperpolarization-activated nonselective cation current I(f) in immortalized HL-1 cardiomyocytes

Lipopolysaccharide (LPS) has been implicated in sepsis-mediated heart failure and chronic cardiac myopathies. We determined that LPS directly and reversibly affects cardiac myocyte function by altering regulation of intracellular Ca(2+) concentration ([Ca(2+)](i)) in immortalized cardiomyocytes, HL-...

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Autors principals: Wondergem, Robert, Graves, Bridget M., Ozment-Skelton, Tammy R., Li, Chuanfu, Williams, David L.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
Matèries:
Receptors and Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944324/
https://ncbi.nlm.nih.gov/pubmed/20573997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00129.2010
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