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A Dyn2–CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding
The epidermal growth factor receptor (EGFR) is over-expressed in a variety of human cancers. Downstream signalling of this receptor is tightly regulated both spatially and temporally by controlling its internalization and subsequent degradation. Internalization of the EGFR requires dynamin 2 (Dyn2),...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944065/ https://ncbi.nlm.nih.gov/pubmed/20711168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.190 |
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