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Expression of the transcription factor ELF4 is regulated by the mTOR pathway in CD8(+) T cells
T cell receptor (TCR) activation inhibits expression of the ELF4 and KLF4 genes to release naïve CD8(+) T cells from their quiescent state. Here we show that ELF4 controls the ERK-mediated proliferative response by maintaining normal levels of DUSP1 and DUSP5 in CD8(+) T cells. In activated CD8(+) T...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943983/ https://ncbi.nlm.nih.gov/pubmed/20802152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000718 |
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