Integrated Ligand-Receptor Bioinformatic and In Vitro Functional Analysis Identifies Active TGFA/EGFR Signaling Loop in Papillary Thyroid Carcinomas

BACKGROUND: Papillary thyroid carcinoma (PTCs), the most frequent thyroid cancer, is usually not life threatening, but may recur or progress to aggressive forms resistant to conventional therapies. A more detailed understanding of the signaling pathways activated in PTCs may help to identify novel t...

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Autori principali: Degl'Innocenti, Debora, Alberti, Chiara, Castellano, Giancarlo, Greco, Angela, Miranda, Claudia, Pierotti, Marco A., Seregni, Ettore, Borrello, Maria Grazia, Canevari, Silvana, Tomassetti, Antonella
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943897/
https://ncbi.nlm.nih.gov/pubmed/20877637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012701
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