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How to Design an Opioid Drug That Causes Reduced Tolerance and Dependence
Mu opioid receptor (MOR) agonists such as morphine are extremely effective treatments for acute pain. In the setting of chronic pain, however, their long-term utility is limited by the development of tolerance and physical dependence. Drug companies have tried to overcome these problems by simply “d...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943346/ https://ncbi.nlm.nih.gov/pubmed/20437553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22002 |
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