E2 Polyubiquitin-conjugating Enzyme Ubc13 in Keratinocytes Is Essential for Epidermal Integrity

The E2 polyubiquitin-conjugating enzyme Ubc13 is a mediator of innate immune reactions. Ubc13 mediates the conjugation of keratin (K)63-linked polyubiquitin chains onto TNF receptor-associated factor 6 and IKKγ during NF-κB activation. In contrast to K48-linked polyubiquitin chains, K63-linked polyu...

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Hlavní autoři: Sayama, Koji, Yamamoto, Masahiro, Shirakata, Yuji, Hanakawa, Yasushi, Hirakawa, Satoshi, Dai, Xiuju, Tohyama, Mikiko, Tokumaru, Sho, Shin, Myoung-Sook, Sakurai, Hiroaki, Akira, Shizuo, Hashimoto, Koji
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943323/
https://ncbi.nlm.nih.gov/pubmed/20663875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.106484
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