Adenosine A(2A) Receptor Signaling and G(olf) Assembly Show a Specific Requirement for the γ(7) Subtype in the Striatum

The adenosine A(2A) receptor (A(2A)R) is increasingly recognized as a novel therapeutic target in Parkinson disease. In striatopallidal neurons, the G-protein α(olf) subtype is required to couple this receptor to adenylyl cyclase activation. It is now well established that the βγ dimer also performs...

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Hlavní autoři: Schwindinger, William F., Mihalcik, Lauren J. Murphree, Giger, Kathryn E., Betz, Kelly S., Stauffer, Anna Maria, Linden, Joel, Herve, Denis, Robishaw, Janet D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943273/
https://ncbi.nlm.nih.gov/pubmed/20639202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.142620
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