The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38(MAPK) Pathways

Elevated plasma free fatty acid (FFA) levels in obesity may play a pathogenic role in the development of insulin resistance. However, molecular mechanisms linking FFA to insulin resistance remain poorly understood. Oxidative stress acts as a link between FFA and hepatic insulin resistance. NADPH oxi...

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Detalhes bibliográficos
Main Authors: Gao, Dan, Nong, Shanwei, Huang, Xiuqing, Lu, Yonggang, Zhao, Hongye, Lin, Yajun, Man, Yong, Wang, Shu, Yang, Jiefu, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943261/
https://ncbi.nlm.nih.gov/pubmed/20647313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128694
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