NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

Dysfunction of β-cell is one of major characteristics in the pathogenesis of type 2 diabetes. The combination of obesity and type 2 diabetes, characterized as ‘diabesity’, is associated with elevated plasma free fatty acids (FFAs). Oxidative stress has been implicated in the pathogenesis of FFA-indu...

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Detalhes bibliográficos
Main Authors: Yuan, Huiping, Zhang, Xiaoyong, Huang, Xiuqing, Lu, Yonggang, Tang, Weiqing, Man, Yong, Wang, Shu, Xi, Jianzhong, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012098/
https://ncbi.nlm.nih.gov/pubmed/21209957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015726
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