Dual specificity phosphatase-1 as a pharmacogenetic modifier of inhaled steroid response among asthma patients

BACKGROUND: Inhaled corticosteroids (ICS) are considered first-line treatment for persistent asthma; yet, there is significant variability in treatment response. Dual specificity phosphatase-1 (DUSP1) appears to mediate the anti-inflammatory action of corticosteroids. OBJECTIVE: To determine whether...

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Main Authors: Jin, Ying, Hu, Donglei, Peterson, Edward L., Eng, Celeste, Levin, Albert M., Wells, Karen, Beckman, Kenneth, Kumar, Rajesh, Seibold, Max A., Karungi, Gloria, Zoratti, Amanda, Gaggin, John, Campbell, Janis, Galanter, Joshua, Chapela, Rocío, Rodríguez-Santana, José R., Watson, H. Geoffrey, Meade, Kelley, LeNoir, Michael, Rodríguez-Cintrón, William, Avila, Pedro C., Lanfear, David E., Burchard, Esteban G., Williams, L. Keoki
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943151/
https://ncbi.nlm.nih.gov/pubmed/20673984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.06.007
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