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MULTICOLOR MONITORING OF DYSREGULATED PROTEIN KINASES IN CHRONIC MYELOGENOUS LEUKEMIA

The Bcr-Abl and Lyn protein tyrosine kinases have been separately linked to the emergence of imatinib resistance in patients with chronic myelogenous leukemia. We have developed fluorescent sensors for these kinases that are enzymatically and photophysically distinct, allowing us to simultaneously,...

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Detalhes bibliográficos
Main Authors: Wang, Qunzhao, Zimmerman, Eric I., Toutchkine, Alexei, Martin, Timothy D., Graves, Lee M., Lawrence, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943031/
https://ncbi.nlm.nih.gov/pubmed/20583816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb100099h
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