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MULTICOLOR MONITORING OF DYSREGULATED PROTEIN KINASES IN CHRONIC MYELOGENOUS LEUKEMIA
The Bcr-Abl and Lyn protein tyrosine kinases have been separately linked to the emergence of imatinib resistance in patients with chronic myelogenous leukemia. We have developed fluorescent sensors for these kinases that are enzymatically and photophysically distinct, allowing us to simultaneously,...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943031/ https://ncbi.nlm.nih.gov/pubmed/20583816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb100099h |
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