Similar levels of mRNA from the W1282X and the delta F508 cystic fibrosis alleles, in nasal epithelial cells.

The effect of nonsense mutations on mRNA levels is variable. The levels of some mRNAs are not affected and truncated proteins are produced, while the levels of others are severely decreased and null phenotypes are observed. The effect on mRNA levels is important for the understanding of phenotype-ge...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Shoshani, T, Kerem, E, Szeinberg, A, Augarten, A, Yahav, Y, Cohen, D, Rivlin, J, Tal, A, Kerem, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294164/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7512981/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117128
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