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Genome-wide screen identifies Escherichia coli TCA cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA
Single-gene mutants with extended lifespan have been described in several model organisms. We performed a genome-wide screen for long-lived mutants in Escherichia coli which revealed strains lacking TCA cycle-related genes that exhibit longer stationary phase survival and increased resistance to hea...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2941539/ https://ncbi.nlm.nih.gov/pubmed/20707865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2010.00618.x |
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