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E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase

We have previously shown that both the hypoxia-inducible transcription factor ArcA and the PoxB/Acs bypass of the pyruvate dehydrogenase complex contribute to extended lifespan in Escherichia coli. In agreement with studies in higher eukaryotes, we also demonstrated that long-lived E. coli mutants,...

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Библиографические подробности
Опубликовано в: :Biol Chem
Главные авторы: Gonidakis, Stavros, Finkel, Steven E., Longo, Valter D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403634/
https://ncbi.nlm.nih.gov/pubmed/20707605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/BC.2010.120
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