Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins

Pilot-scale libraries of eight-membered medium ring lactams (MRLs) and related tricyclic compounds (either seven-membered lactams, thiolactams or amines) were screened for their ability to inhibit the catalytic activity of human recombinant 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase i...

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Main Authors: PERCHELLET, JEAN-PIERRE H., PERCHELLET, ELISABETH M., CROW, KYLE R., BUSZEK, KEITH R., BROWN, NEIL, ELLAPPAN, SAMPATHKUMAR, GAO, GE, LUO, DIHENG, MINATOYA, MACHIKO, LUSHINGTON, GERALD H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941436/
https://ncbi.nlm.nih.gov/pubmed/19787197
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