Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice

OBJECTIVE: Humanin, an endogenous anti-apoptotic peptide, has previously been shown to protect against Alzheimer’s disease and a variety of cellular insults. We evaluated the effects of a potent analog of humanin, HNG, in an in vivo murine model of myocardial ischemia and reperfusion (MI-R). METHODS...

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Autors principals: Muzumdar, Radhika H., Huffman, Derek M., Calvert, John W., Jha, Saurabh, Weinberg, Yoni, Cui, Lingguang, Nemkal, Anjana, Atzmon, Gil, Klein, Laura, Gundewar, Susheel, Ji, Sang Yong, Lavu, Madhav, Predmore, Benjamin L., Lefer, David J.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941397/
https://ncbi.nlm.nih.gov/pubmed/20651283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.205997
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