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Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells

Casitas B-cell lymphoma (Cbl)-family E3 ubiquitin ligases are negative regulators of tyrosine kinase signaling. Recent work has revealed a critical role of Cbl in the maintenance of hematopoietic stem cell (HSC) homeostasis, and mutations in CBL have been identified in myeloid malignancies. Here we...

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Библиографические подробности
Главные авторы: Naramura, Mayumi, Nandwani, Neha, Gu, Hua, Band, Vimla, Band, Hamid
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941297/
https://ncbi.nlm.nih.gov/pubmed/20805496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007575107
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