Familial hemiplegic migraine Ca(V)2.1 channel mutation R192Q enhances ATP-gated P2X(3 )receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

BACKGROUND: The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of voltage-gated P/Q Ca(2+ )channels (Ca(v)2.1), is associated with familial hemiplegic migraine-1. We investigated whether this gain-of-function mutation changed the structure and function of trigeminal neuron P2X(3 )re...

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Hlavní autoři: Nair, Asha, Simonetti, Manuela, Birsa, Nicol, Ferrari, Michel D, van den Maagdenberg, Arn MJM, Giniatullin, Rashid, Nistri, Andrea, Fabbretti, Elsa
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940876/
https://ncbi.nlm.nih.gov/pubmed/20735819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-48
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