Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.

Directed migration or chemotaxis of arterial smooth muscle cells (SMC) contributes to intimal SMC accumulation, a key event in the development of atherosclerotic lesions and in restenosis after angioplasty. The present study compares and contrasts insulin-like growth factor I (IGF-I) and platelet-de...

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Опубликовано в: :J Clin Invest
Главные авторы: Bornfeldt, K E, Raines, E W, Nakano, T, Graves, L M, Krebs, E G, Ross, R
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 1994
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294079/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8132765/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117081
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