The HA and NS Genes of Human H5N1 Influenza A Virus Contribute to High Virulence in Ferrets

Highly pathogenic H5N1 influenza A viruses have spread across Asia, Europe, and Africa. More than 500 cases of H5N1 virus infection in humans, with a high lethality rate, have been reported. To understand the molecular basis for the high virulence of H5N1 viruses in mammals, we tested the virulence...

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Detalles Bibliográficos
Autores principales: Imai, Hirotaka, Shinya, Kyoko, Takano, Ryo, Kiso, Maki, Muramoto, Yukiko, Sakabe, Saori, Murakami, Shin, Ito, Mutsumi, Yamada, Shinya, Le, Mai thi Quynh, Nidom, Chairul A., Sakai-Tagawa, Yuko, Takahashi, Kei, Omori, Yasuyuki, Noda, Takeshi, Shimojima, Masayuki, Kakugawa, Satoshi, Goto, Hideo, Iwatsuki-Horimoto, Kiyoko, Horimoto, Taisuke, Kawaoka, Yoshihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940759/
https://ncbi.nlm.nih.gov/pubmed/20862325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001106
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