PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541

IGF-1 receptor signaling contributes to the growth of many solid tumors, including glioblastoma. This study analyzed the sensitivity of 8 glioblastoma cultures to the IGF-1 receptor inhibitor NVP-AEW541. Growth reduction, caused by a combination of antiproliferative and proapoptotic effects, varied...

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Detalles Bibliográficos
Main Authors: Hägerstrand, Daniel, Lindh, Maja Bradic, Peña, Cristina, Garcia-Echeverria, Carlos, Nistér, Monica, Hofmann, Francesco, Östman, Arne
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
Assuntos:
Basic and Translational Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940698/
https://ncbi.nlm.nih.gov/pubmed/20378689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq029
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