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Expression of synaptic vesicle protein 2A in epilepsy-associated brain tumors and in the peritumoral cortex

Synaptic vesicle protein 2A (SV2A) has been identified as the binding site for the antiepileptic drug levetiracetam and is thought to decrease neuronal excitability. Since knockout of SV2A in mice leads to seizures, we hypothesized that a reduction in SV2A expression promotes seizure generation in e...

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Autors principals: de Groot, Marjolein, Toering, Sjoukje T., Boer, Karin, Spliet, Wim G.M., Heimans, Jan J., Aronica, Eleonora, Reijneveld, Jaap C.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940585/
https://ncbi.nlm.nih.gov/pubmed/20167814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop028
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