Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy

PURPOSE: Adenosine kinase (ADK), a largely astrocyte-based metabolic enzyme, regulates adenosine homeostasis in the brain. Overexpression of ADK decreases extracellular adenosine and consequently leads to seizures. We hypothesized that dysfunction in the metabolism of tumor astrocytes is related to...

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Autors principals: de Groot, Marjolein, Iyer, Anand, Zurolo, Emanuele, Anink, Jasper, Heimans, Jan J., Boison, Detlev, Reijneveld, Jaap C., Aronica, Eleonora
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253237/
https://ncbi.nlm.nih.gov/pubmed/22092111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2011.03306.x
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