Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy

PURPOSE: Adenosine kinase (ADK), a largely astrocyte-based metabolic enzyme, regulates adenosine homeostasis in the brain. Overexpression of ADK decreases extracellular adenosine and consequently leads to seizures. We hypothesized that dysfunction in the metabolism of tumor astrocytes is related to...

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Bibliografiska uppgifter
Huvudupphovsmän: de Groot, Marjolein, Iyer, Anand, Zurolo, Emanuele, Anink, Jasper, Heimans, Jan J., Boison, Detlev, Reijneveld, Jaap C., Aronica, Eleonora
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253237/
https://ncbi.nlm.nih.gov/pubmed/22092111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2011.03306.x
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