Chronic Corticosterone Exposure Increases Expression and Decreases Deoxyribonucleic Acid Methylation of Fkbp5 in Mice

There is evidence for hypercortisolemia playing a role in the generation of psychiatric symptoms and for epigenetic variation within hypothalamic-pituitary-adrenal (HPA) axis genes mediating behavioral changes. We tested the hypothesis that expression changes would be induced in Fkbp5 and other HPA...

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Hlavní autoři: Lee, Richard S., Tamashiro, Kellie L. K., Yang, Xiaoju, Purcell, Ryan H., Harvey, Amelia, Willour, Virginia L., Huo, Yuqing, Rongione, Michael, Wand, Gary S., Potash, James B.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Endocrine Society 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940504/
https://ncbi.nlm.nih.gov/pubmed/20668026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0225
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