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CYP24A1 Inhibition Enhances the Antitumor Activity of Calcitriol
High systemic exposures to calcitriol are necessary for optimal antitumor effects. Human prostate cancer PC3 cells are insensitive to calcitriol treatment. Therefore, we investigated whether the inhibition of 24-hydroxylase (CYP24A1), the major calcitriol inactivating enzyme, by ketoconazole (KTZ) o...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Endocrine Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2940491/ https://ncbi.nlm.nih.gov/pubmed/20591973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-1156 |
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