Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase

The enzyme 6-phosphogluconate dehydrogenase is a potential drug target for the parasitic protozoan Trypanosoma brucei, the causative organism of human African trypanosomiasis. This enzyme has a polar active site to accommodate the phosphate, hydroxyl and carboxylate groups of the substrate, 6-phosph...

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Hlavní autoři: Ruda, Gian Filippo, Campbell, Gordon, Alibu, Vincent P., Barrett, Michael P., Brenk, Ruth, Gilbert, Ian H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939770/
https://ncbi.nlm.nih.gov/pubmed/20598892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.05.077
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