Intrathecal Delivery of a Mutant μ-Opioid Receptor Activated by Naloxone as a Possible Antinociceptive Paradigm

Direct injection of double-stranded adeno-associated virus type 2 (dsAAV2) with a μ-opioid receptor (MOR) mutant [S4.45(196)A], and a reporter protein (enhanced green fluorescent protein) into the spinal cord (S2/S3) dorsal horn region of ICR mice resulted in antinociceptive responses to systemic in...

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Autori principali: Kao, J. H., Chen, S. L., Ma, H. I., Law, P. Y., Tao, P. L., Loh, H. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2010
Soggetti:
Chemotherapy, Antibiotics, Abd Gene Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939678/
https://ncbi.nlm.nih.gov/pubmed/20554907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.165399
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